• At MSU has studied Taiwanese mutants

  • Scientists of the faculty of fundamental medicine, Moscow state University, investigated the molecular mechanisms occurring in early stages of Alzheimer's disease. This will create a new drug that stops the progression of the disease, according to a press release received by "the Ribbon.ru".

    Many of the native peptides with a mutation of the Taiwan Alzheimer's disease develops at a relatively young age. Experts have studied the mechanisms of accumulation of beta-amyloid peptide produced in the early stages of the disease in the brains of people.

    Often beta-amyloid proteases are cut and recycled after the performance of its functions, but in rare cases they are associated with each other and form toxic to neurons complexes. In the model object they choose just the mutant peptides, making their bond is more durable.

    The study's lead author Vladimir Bolshakov said that the interaction of metal ions with beta-amyloid usually leads to many different conformations of the peptide chain: "In the case of Taiwan product of mutation was observed in a single conformation, which allowed us to accurately determine its structure by the methods of nuclear magnetic resonance". He also added that similar binuclear structures have not been described in the world literature.

    Researchers from the Institute of molecular biology has already patented two compounds that may hamper the creation of such a zinc-dependent relationships. Tests have shown that it helps to reduce the risk of developing Alzheimer's disease several times.


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