Scientists of the faculty of fundamental medicine, Moscow state University, investigated the molecular mechanisms occurring in early stages of Alzheimer's disease. This will create a new drug that stops the progression of the disease, according to a press release received by "the Ribbon.ru".
Many of the native peptides with a mutation of the Taiwan Alzheimer's disease develops at a relatively young age. Experts have studied the mechanisms of accumulation of beta-amyloid peptide produced in the early stages of the disease in the brains of people.
Often beta-amyloid proteases are cut and recycled after the performance of its functions, but in rare cases they are associated with each other and form toxic to neurons complexes. In the model object they choose just the mutant peptides, making their bond is more durable.
The study's lead author Vladimir Bolshakov said that the interaction of metal ions with beta-amyloid usually leads to many different conformations of the peptide chain: "In the case of Taiwan product of mutation was observed in a single conformation, which allowed us to accurately determine its structure by the methods of nuclear magnetic resonance". He also added that similar binuclear structures have not been described in the world literature.
Researchers from the Institute of molecular biology has already patented two compounds that may hamper the creation of such a zinc-dependent relationships. Tests have shown that it helps to reduce the risk of developing Alzheimer's disease several times.
Researchers from Loma Linda University (USA) showed that the largest share of calories daily diet should have for Breakfast, and the minimum for dinner. This allows you to keep a normal and stable body mass index. A study published in the Journal of Nutrition.
An unusual signal, which, as previously thought, comes from the red dwarf Ross 128 and may be associated with extraterrestrial civilizations, has a terrestrial origin. "The signal is likely generated by one or more satellites," said Professor Abel Mendez from the University of Puerto Rico.
A group of mathematicians explained the emergence of the grandmothers. According to the theory called "grandmother hypothesis" that menopause is explained by the need to help the younger generation to raise children that increases the chances of further transmission of their genes. However, this theory does not explain when it came grandmother.
The UN Security Council on Monday, July 24, will hold an extraordinary meeting on the situation in Jerusalem, where the clashes between the Palestinians and the Israelis killed several people. The discussion will take place behind closed doors after the morning session of the Council.
The fighting was interrupted Donetsk filtration station. The power supply has been disconnected at 19:25 on Saturday, July 22. Stopped water supply to the city of Avdeevka, partly Donetsk and Yasinovataya, towns Verkhnetoretskoye, Red Partisans, and the village Vasilevka and Kruta Balka.
The head of homeland security and the US cyber command Admiral Michael Rogers believes that now is not the time to create a joint Russian-American group on cyber security. Such opinion as transfers RIA Novosti, he said during a forum on security.