• At MSU have studied the process of self-destruction of cells

  • MSU scientists described the mechanisms of the influence of post-translational modifications (PTM) of proteins of the caspase family in the process of their activation and the occurrence of programmed cell death — apoptosis. This study helps to predict new modification sites caspase, said in a press release received by "the Ribbon.ru".

    As noted by the head of the laboratory of investigation of mechanisms of apoptosis Boris Zhivotovsky, disturbances in the mechanism of the start and occurrence of apoptosis can lead to the destruction of neurons, as well as hematologic, immune, metabolic disease. This process provide special proteins-enzymes — caspases. Their activation contributes to a number of factors, among which improving temperature, DNA damage, and many other.

    "PTM play a key role in the regulation of activation and subsequent caspase activity, thereby playing the role of switches between programmed cell death and their survival, as demonstrated clearly in the article," — said the participant of the study Evgeny Prokhorov.

    In their work, scientists studied more than 250 sources, to identify the main types of PTM and their subsequent classification. The focus was, in what conditions are the changes and what they produce. Along with this was a comparative bioinformatics analysis of amino acid sequences of each caspase in vertebrates and invertebrates.

    The resulting data will allow you to create special activators to adjust caspase activity. This, in turn, can be used in the treatment of neurodegenerative and cancer diseases associated with dysfunction of proteases.

    http://lenta.ru

More news in the same category:

    • Img
    • 7:06 am on Tuesday 28th March 2017  /  Наука и техника
      In the Solar system found electric moon

      American scientists have shown that the triboelectric effect (the appearance of electric charges in the material due to friction) responsible for the anomalous orientation of large dunes of Titan (the largest moon of Saturn). A study published in the journal Nature Geoscience.

    • Img
    • 3:51 am on Tuesday 28th March 2017  /  Наука и техника
      Elon Max decided to create a technology to connect the brain with computers

      The founder of SpaceX and Tesla Motors Elon Musk created a company Neuralink, which will develop methods to read data from the human brain and record them to the media. According to The Wall Street Journal, talking about the technology of "neural lace", which involves the implantation of electrodes into the brain.

    • Img
    • 12:05 am on Tuesday 28th March 2017  /  Наука и техника
      The Sun found signs of the planet

      American astrophysicists has discovered in the Sun, waves, Rossby, previously observed only on Earth. For this, the authors used data from the spacecraft SDO (Solar Dynamics Observatory) and STEREO (Solar TErrestrial RElations Observatory). A study published in the journal Nature Astronomy.

More Global News:

    • Img
    • 8:45 am on Tuesday 28th March 2017  /  Мир
      Trump proposed to investigate Clinton ties with Russia

      The President of the United States Donald trump proposed to the house Committee on intelligence to investigate relations with Russia former Secretary of state Hillary Clinton and a number of representatives of the democratic party. We are talking about "the deal, which allowed a considerable proportion of uranium go to Russia", as well as the reset of relations between Moscow and Washington.

    • Img
    • 8:27 am on Tuesday 28th March 2017  /  Интернет и СМИ
      The network has sympathized sad the bulldog is a birthday without guests

      A Twitter user with the nickname @NasMaraj published a picture of a sad bulldog and told the story about how none of the neighborhood dogs came to the party in honor of his birthday. The gained viral popularity, but later the owner of the account said that he invented the holiday, and the dog.

    • Img
    • 7:58 am on Tuesday 28th March 2017  /  Бывший СССР
      Four employees of the Ministry of transport of Kyrgyzstan was killed in the avalanches

      Avalanche has covered three cars on the 255-kilometer strategic highway Bishkek-Osh in Kyrgyzstan. In one of them were four employees of the Ministry of transport and roads of the Republic they died on the spot. Six others rescuers managed to extract from under the rubble alive.

comments powered by Disqus